ADR381
Production
The ADR380 and ADR381 are precision 2.048 V and 2.500 V band gap voltage references featuring high accuracy, high stability, and low power consumption...
Datasheet
ADR381 on Analog.com
I am using a cascode pair of JFETS with an ADR381 to make a 4mA constant current source.
This is a classic circuit that works fine with other pin compatible voltage references.
In my working circuit:
Vout - GND is 2.50V, Vin is 3.4V when loaded.
If I use the ADR381, then
Vout - GND is 1.60V, Vin is 0V when loaded.
If the circuit is open, then
Vout is 1.0V in the working circuit and 1.6V in the ADR381
Vin = 0V which makes sense with the FETs cutoff.

I can't see why the ADR381 fails in this circuit. Any suggestions, explanations or simple fixes would be appreciated. I own a lot of ADR381 parts right now.
BTW: R128 = 324 so 2.5/((300+324) = 4mA