ADV7182A very low current from all power rails

Thanks for your quick reply.

Sorry, but I don't understand your suggestion.

Most I2C devices use 7-bit addressing and I2C software is expecting 7-bit addresses.  ADI video device scripts use 8-bit addressing.  Try taking the 8-bit address, shift it right by one (turns it into a 7-bit address) and use that as input to your software.  

8-bit >>1 => 7-bit => i2C software which left shifts by one and appends the read/write bit making the 8 bits that show up on the bus.  Basically using 8 bit  addressing means all odd addresses are reads and all even addressing are writes.  A bit confusing but is works.

0x20 => 0x10, so you send 0x10 to the I2C software.  The software will convert it back to an 8-bit packet with the read/write bit added.

Not answer to those address:

0x10 to 0x14

0x20 to 0x24

0x40 to 0x44 

Any additional suggestions ?

1) schematic looks good.

2) 8-bit addressing issue has been addressed

3) This assumes RESET and PWRDWN are both high

4) assumes EPad is really tied to ground.

5) other I2C devices on the same 1.8V I2C works

? Exactly how are you implementing the 1.8V I2C bus?  

Beyond this I am running out of items to check.