I can use 12V for the single supply for VDD? However, to avoid using level shifters I would like to use either 3.3V or 2.5V for the logic, specifically SCL and SDA.
Yes, you may use the ADG2188 with single supply VDD = 12V. This was mentioned at the Specifications section of the datasheet.
For VL supply, you might want to use the 3.3V logic as this was implemented and working in the ADG2188 evaluation board. I would not recommend using VL = 2.5V as this was not tested with the ADG2188 and the 2.5V level might not be enough to power-up the digital block so performance of the device is not guaranteed.
In summary, the ADG2188 can be used with single supply VDD=12V and logic supply VL=3.3V.
Let me know if this helps.
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