Is the following a mistake in the datasheet?
Max voltage +Vs -25V
Min Voltage -Vs +25V
Specifically, would the inputs actually be overvoltage protected to +/-25V from a single supply Vs (say 3.3V or 5V)
No, that is not a mistake in the datasheet. The inputs would actually be overvoltage protected to +/-25V. Please see the Input Voltage Protection section on page 12 of the datasheet.
So say you use a 5V supply, your inputs would be able to withstand voltages from -20V to +25V as taken from the specifications.
I hope this helps!
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