What are my primary concerns when using the profile pins?
With multiple profile pins, changes must meet the setup and hold times to the rising edge of the SYNC_CLK with one exception (see below). If not, the wrong profile may be selected. Having low skew times between multiple profile edges can aid in meeting critical setup and hold times. Also, having fast profile rise and fall times will aid at the higher speeds of SYNC_CLK.
Note, if only one profile line is toggle at a time, the profile change can be asynchronous to the SYNC_CLK.
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