Yes, one of the key benefits of the ADG5248F is that the drain leakage is still
very low (<90nA over temperature), even when there is a fault on one of the
input channels. Most competitor solutions have very high drain leakage when one
of the channels is in fault, meaning the leakage can swamp sensitive
measurements such as signals from Thermocouples. For example, the MAX4508 has
1uA leakage at 85C and 100uA leakage at 125C which would make other channels
completely unusable for sensors sensitive to leakage.
The other solution which customers use for overvoltage protection is using
series resistors to protect multiplexed inputs. The major drawback of that
approach is that an over-voltage event on OFF channels injects noise to good
ON channel due to current flow in substrate leading to corrupt data. With the
ADG52xxF parts, there is no current flow in the substrate ensuring no
corruption of data.