Yes, the ADG5208F/ADG5209F are pin-for-pin compatible with the ADG5208/ADG5209
and ADG1208/ADG1209. They are drop in replacements if overvoltage protection is
required. However, they are not spec-for-spec replacements so there may be some
performance impacts, e.g. higher Ron, higher charge injection. There are no
pin-for-pin alternatives for the ADG5243F, ADG5248F, or ADG5249F.
The ADG54xxF family are the low RON alternative. They have been built using the
same high voltage trench isolated process and have been optimized for low on