Can ADG1221/ADG1222 work at single 5V supply？ And what range is the input analog signal at this situation. Thanks.
Yes, the ADG1221/ADG1222 is operational at 5 V single supply. You may have a look at the Power Requirement Section of the Specifications Table 2 of the datasheet on page 5. Vdd V min is 5V and V max is 16.5 V.
Analog Signal Range is from 0 V to Vdd.
Let me know if this helps.