I would like to drive the ADRF6516 with 1MHz Single ended input, whether it is possible to drive in single ended configuration
All of the characterization was done while being drivnig differentially. I'm researching your question right now and will get back to you in a day or so.
You can drive the ADRF6516 single ended if you AC ground (via a large capacitor to ground) the unused input, but degraded distortion wll occur when comparing the same input amplitude and frequency to the differential case. A 0.5 Vpp single ended signal is the max recommended to still get decent distortion numbers (about 55-58 dBc). Also, distorion will degrade as you increase frequency.