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Signal smaller than the ADC’s input range

My signal is smaller than the ADC’s input range. Should I gain up the signal to match the full input range?

[edited by: EstiS at 7:47 AM (GMT -4) on 20 May 2021]
  • Set the signal chain gain so that the amplifiers' total noise is the same or a bit less than the ADC's.

    Any higher gain makes the ADC driver work harder without helping the system SNR.

    Don't feel obligated to gain the signal up to match the ADC's full input range unless that helps system SNR