AD8436 is this a valid power supply and gain configuration?

Please see attached schematic.

Note this is the QSOP20 package

The input range is between 100mV and 1.4Vrms @ LHS of C4

The AD8436 output buffer is configured for a gain of 10, so up to 14Vdc at pin 15

Power supply is configured for non-bi-polar operation

Is it okay to use a 21V supply only at pin 16, or is it better to use +21V at pins 16, 17 and 18?

Do you see any issues with this configuration?