SigmaStudio includes an API that can be used by Windows COM/OLE and Pythons' win32com library can access that. While the ADI documents provide the API calls, there aren't any provided examples of the functions being used. It also turns out that API calls that return a value don't work as expected.
This app note works through an example of reading a remote temperature sensor over A2B from a (Windows) Python program.
https://clk.works/2020/09/a2b-control-from-python-via-sigmastudio-appnote003/