There are no known issues with lock up for the DS2482-100 device. That said, be careful with the 1-Wire master (any 1-Wire master) when connecting it to temperature sensors, EEPROM memories, or anything that would require a strong pullup. For example, take the DS18B20 temp sensor. It can consume a maximum current of 1.5mA during temperature conversions or EEPROM writes, so a strong pullup is necessary to avoid the voltage drop on the 1-Wire pin, which would violate the operating voltage. The external 1.5k pullup and the DS2482’s internal pullup are not stiff enough to supply the current without dropping too much voltage. So, make sure to give the DS2482-100 the command to perform a strong 1-Wire pullup when it is needed. Also, do not try sending a mass temperature conversion to where all of the 1-Wire devices simultaneously perform a conversion. Instead, address each 1-Wire device on the same bus separately and perform a temperature conversion only on one device at a time.
The DS2482-100 device pulls the 1-Wire line to 3.3V (instead of 5V like other 1-Wire masters). The DS18B20 has a minimum of 3.0V pullup supply voltage requirement, making it crucial to engage a strong pullup.
Also, take a look at the last device on the 1-Wire bus and determine if the 1-Wire supports the min pull up voltage else reduce the external pullup resistor value to 1.1K and lower to make sure min voltage is supported.