The problem with Win 10 occurs when the USB Bridge IC on the ISEB motherboard is programmed with the ADI settings. When it’s programmed with the ADI settings the ADI driver must be installed on the host computer and it is not compatible with Win 10. For boards released after 2018 we don’t have this issue.
To fix this issue, you need to re-program the bridge with the Silicon Lab setting. In the attachment below, there's a screen capture showing the values that must be set to program. NOTE: It’s important to click on the check box next to each parameter that need to be re-programed. This reprogramming is done with the “CP210xSetIDs”. Here attached a copy of the CP210xSetIDs application as well as a copy of the Silicon Lab USB Driver.
The ISEB USB Drivers.zip file contains two zip files: