ADUM1251/ADUM1250 Isolation

I am investigating the ADUM1250/1251 devices for an I2C isolation application.

My concern is that it appears both VDD pins are considered to be supply pins because the datasheet lists a sink current for both VDD1 and VDD2.  If both pins are sinking current and powering the device, will the device still be able to provide isolation on the power rail?

Also, we plan to use the chip to prevent latchup when hot plugging a non-powered device into a powered device.  Will the ADUM1251 need to place on the non-powered device or the powered device?

Thanks in advance.

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