ADM2486 Ground connection

Hello,

One customer is reviewing the ADM2486 for UART to RS485 converting.

1. Datasheet noticed the Vdd2 can only be 5V, I just want to know if 3.3v works or not. 

2. Is there any problem for operation to connect GND1 and GND2 without isolation?

Thanks,

Gabe.

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