ADRV9009-ZU11EG Multi-SOM: "Re-initialization due to lock-up" issues before "Unable to initialize"

I had a working multi-som system last Thursday, but today I'm seeing errors when trying to connect to the SOMs:

--Connecting to device(s)
Re-initializing due to lock-up
Re-initializing due to lock-up
Re-initializing due to lock-up
Exception in Tkinter callback
Traceback (most recent call last):
  File "/usr/lib/python3.8/tkinter/", line 1892, in __call__
    return self.func(*args)
  File "./", line 120, in <lambda>
    TxApplyB = tk.Button(root, text='Apply', command= lambda: setTx(), width=9, bg='green')
  File "./", line 808, in setTx
  File "./", line 1182, in connectSOMs
  File "/usr/local/lib/python3.8/dist-packages/pyadi_iio-0.0.8-py3.8.egg/adi/", line 424, in rx
  File "/usr/local/lib/python3.8/dist-packages/pyadi_iio-0.0.8-py3.8.egg/adi/", line 412, in _pre_rx_setup
    raise Exception("Unable to initialize (Board reboot required)")
Exception: Unable to initialize (Board reboot required)

I'm running my software on Ubuntu 20.04.2 LTS and as far as I know the system has been turned off except for the Ubuntu machine.

Is it possible an automatic update has broken something?

Are there any steps I can take to help troubleshoot the problem?

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