There are three main analog to digital converter input architectures -- Single Ended, Differential Input, Pseudo Differential. Each has its own advantages and disadvantages. The choice of ADC input architecture is based upon the application and the signal of interest. These different types of analog to digital converter input types is further explained in details in this article by Ryan Curran, ""Exploring Different SAR ADC Analog Input Architectures"" http://www.analog.com/en/technical-articles/exploring-different-sar-adc-analog-input-architectures.html"
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