Question
How often can I write to the AD5141’s internal EEPROM?
Answer
It depends on the temperature, typical 1Mcycle @ 25C, minimum 100k cycles.
AD5121
Production
The AD5121/AD5141 potentiometers provide a nonvolatile
solution for 128-/256-position adjustment applications, offering
guaranteed low resistor tolerance...
Datasheet
AD5121 on Analog.com