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Can I leave SDO open, or is there any reason I must connect a pull-up to SDO?
The AD5290 SDO , is a Serial Data Output Pin. it has an Internal N-Ch FET with open-drain output. Even thought you do not use it. it can be left open.... but good practise, i have done in the past is to tie it off with a pull-up to avoid noise and high impedance feedback. just in case. Anyway having a resistor (e.g. 0605 or smaller) option designed in. you can pop and depopulate this at will later in the design as you see fit.