AD5543/AD5553

Yes, You can provide 100mV at VREF.

Any specific reason why you want to drive 100mV at VREF? Do note that you will not get nA current with this.

Thanks for your response,

I want to get 1uA to 200uA current with resolution of 3nA while applying 100mV. And one thing more , I think we need to put -100mV as in equation there is negative.
The resolution and min/max current this circuit can be provided with -100mV? I am expecting max current of 200uA.

You cannot interpolate or extrapolate 10V performance data to other reference values without applying correction and accordingly assume lower current, as the DC errors like linearity, offset, gain do not scale down/up proportionally with VREF.

You need a different circuit design in this case.

Is there any application note or IC: Which can help us to achieve the up-to programmable source max current of 200uA.

What compliance voltage range do you require? There may not be a single-chip solution that does exactly what you need, so you might be better off using a voltage output DAC followed by a voltage to current converter, such as a Howland current pump:

https://www.analog.com/en/analog-dialogue/articles/a-large-current-source-with-high-accuracy-and-fast-settling.html

Here's another article that may come in useful:

https://www.analog.com/en/analog-dialogue/articles/current-output-circuit-techniques-add-versatility.html 

-Mark

What compliance voltage range do you require? There may not be a single-chip solution that does exactly what you need, so you might be better off using a voltage output DAC followed by a voltage to current converter, such as a Howland current pump:

https://www.analog.com/en/analog-dialogue/articles/a-large-current-source-with-high-accuracy-and-fast-settling.html

Here's another article that may come in useful:

https://www.analog.com/en/analog-dialogue/articles/current-output-circuit-techniques-add-versatility.html 

-Mark