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AD5308 Serial Interface?

Here is my question.

We want to send the AD5308 a 10-bit value instead of 8-bit for reasons of software compatibility.

The AD53x8 datasheet isn’t clear on this, it says:

The AD5318 uses 10 bits and ignores the 2 LSBs. The AD5308 uses 8 bits and ignores the

last 4 bits. These ignored LSBs should be set to 0."

So our question is, what if those extra LSBs are NOT set to zero, will that be a problem?