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AD5263 (AD5263BRUZ20) Query

I am planning to use DigiPot AD5263BRUZ20 ( Digital Potentiometer  IC Quad 8-Bit I2C) in my H/W setup for gain setting. Earlier it has 4 potentiometer in design (not digital pot), now I want to replace it with Digipot. Each digipot (out of 4) will be having different resistance value and need to be there all time.

My queries are:

1) Does AD5263BRUZ20 has independent pot settings?

2) Since digital lines for all pots are same, will all 4 pot's will be active same time with different resistance value?

3) Is there any other suitable part having 4 channels?