Q: The AD7606 can measure across +/-5V or +/-10V but I don’t really need to measure negative voltages. Can I configure the AD7606 to measure across the unipolar range and still get 16 bits resolution?
A: The AD7606 is optimized for +/-5V and +/-10V input conditions; using half the range will result in a loss of resolution. You can opt to use AD7608, the 18-bit pin compatible solution to the AD7606, using half the range may give you your required end resolution.