I can not see the components very clearly in your schematic. Could you provide a more clear schematic instead?
(1) Could you provide more details about your application, like Vin, Vout, fs, Io_max, single output?
(2) Meanwhile, could you provide more info about your power up condition? If there is no proper output after RUN is high, let's check the NVM setting first. Default NVM setting is for dual outputs application.
PDF
thanks，
there is no connect with I2C