If protection is enabled on the ADA4254, it will open the MUX inputs if an overvoltage is detected. For example, if +IN1/-IN1 see an excessive voltage, those mux inputs will be disconnected, protecting the internal amplifier.
However, what happens when the second set of inputs that are already open have an overvoltage event? For example what if +IN1/-IN1 are in use but +IN2/-IN2 sees in overvoltage event? Will +IN1/-IN1 be disconnected?