The datasheet for the ADA4841 says that the exposed paddle of the LFCSP package should be connected to ground (Figure 3 on first page). In a split supply design is that Ground (0V) or is it the negative supply?
The exposed pad is for heat dissipation. It should e connected to GND.
The question is what you consider GND. Is GND the negative supply or the system GND. For example, if I have +Vs (Pin 8) connected to +5V and -Vs (Pin 4) connected to -5V, is the exposed pad connected to 0V or to -5V?
Either you power it with dual or single supply, it's the 0V that we'll consider GND.